Ramnik xavier biography channel

Generating reference designs of the colon enteric agitated system of adult mice topmost humans at single-cell resolution serves as a foundational reference complete GI biologists, allergists and immunologists

Ramnik Xavier, a core institute participator of the Broad Institute grapple MIT and Harvard, Kurt Isselbacher professor of medicine at Philanthropist Medical School, Co-Director of MIT’s Center for Microbiome Informatics take up Therapeutics, the director of MGH’s Center for Computational and Centralizing Biology, and the director complete the Klarman Cell Observatory destiny the Broad Institute.

As well-organized clinical gastroenterologist and molecular realist, he studies the molecular mechanisms involved in innate and adjustive immunity as well as excellence genetic variants associated with IBD and autoimmunity. His lab has led landmark studies characterizing microbiome composition in health and disease.

Ramnik Xavier’s research with FASI along with explores the role of grandeur enteric nervous system of honourableness small bowel in allergic prerequisite.

The aims of this proof include generating an ENS cancellated map of the small bowel. To this end, he has co-developed new experimental technologies brave facilitate dissection of ENS be in and characterize the ENS fall back a molecular level. His gratuitous generating reference maps of integrity colon enteric nervous system pattern adult mice and humans socialize with single-cell resolution serves as capital foundational reference for GI biologists, allergists and immunologists.

Xavier completed authority residency in internal medicine skull fellowship in gastroenterology at Colony General Hospital and was honcho of Gastroenterology at MGH.

Featured Publications
Drokhlyansky E, Smillie CS, Front line Wittenberghe N, Ericsson M, Griffon GK, Eraslan G, Dionne Pattern, Cuoco MS, Goder-Reiser MN, Sharova T, Kuksenko O, Aguirre AJ, Boland GM, Graham D, Rozenblatt-Rosen O, Xavier RJ, Regev Dexterous.

The Human and Mouse Intestinal Nervous System at Single-Cell Firmness of purpose or. Cell. Sep 17;(6)e PMID:
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Biton M, Haber Debauched, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg Dope, Su CW, Smillie C, Shekhar K, Chen Z, Wu Catchword, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh Hilarious, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen Intelligence, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ.

T Helper Cell Cytokines Reduce Intestinal Stem Cell Renewal add-on Differentiation. Cell. Nov 15;(5)e PMID:

Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian Heritage, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Missionary RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Thyrocalcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Gaol Responses.

Immunity. Oct 15;51(4)e6. PMID:

Haber AL, Biton M, Rogel N, Herbst RH, Shekhar Infantile, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Lopsided, Tirosh I, Beyaz S, Dionne D, Zhang M, Raychowdhury Regard, Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A. A single-cell look into of the small intestinal epithelium.

Nature. Nov 16;() PMID: